Homo sapiens Gene: CARS
Summary
InnateDB Gene IDBG-23884.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CARS
Gene Name cysteinyl-tRNA synthetase
Synonyms CARS1; CYSRS; MGC:11246
Species Homo sapiens
Ensembl Gene ENSG00000110619
Encoded Proteins
cysteinyl-tRNA synthetase
cysteinyl-tRNA synthetase
cysteinyl-tRNA synthetase
cysteinyl-tRNA synthetase
cysteinyl-tRNA synthetase
cysteinyl-tRNA synthetase
cysteinyl-tRNA synthetase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:3000922-3057613
Strand Reverse strand
Band p15.4
Transcripts
ENST00000380525 ENSP00000369897
ENST00000278224 ENSP00000278224
ENST00000397111 ENSP00000380300
ENST00000439280 ENSP00000408802
ENST00000466442
ENST00000470221
ENST00000484484
ENST00000465240
ENST00000465207
ENST00000465331
ENST00000531387 ENSP00000431368
ENST00000526890
ENST00000529772 ENSP00000432619
ENST00000524825
ENST00000527330 ENSP00000434184
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 32 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004817 cysteine-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006423 cysteinyl-tRNA aminoacylation
GO:0010467 gene expression
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Cytosolic tRNA aminoacylation pathway
tRNA Aminoacylation pathway
Gene Expression pathway
KEGG
Aminoacyl-tRNA biosynthesis pathway
INOH
Methionine Cysteine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.274873
RefSeq NM_001014437 NM_001194997 NM_001751 NM_139273 XM_006718340 XM_006718341 XM_006725130
HUGO
OMIM
CCDS CCDS41600 CCDS41602 CCDS7742
HPRD 00464
IMGT
EMBL
GenPept
RNA Seq Atlas