Version 5.4
Mus musculus Gene: Ppfia1
Summary
InnateDB Gene IDBG-212905.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppfia1
Gene Name protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000037519
Encoded Proteins
IDBP-619976
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
IDBP-788547
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
IDBP-788548
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
IDBP-788550
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131626:
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:144476758-144553729
Strand Reverse strand
Band F5
Transcripts
ENSMUST00000168134 ENSMUSP00000126233
ENSMUST00000182982
ENSMUST00000182958 ENSMUSP00000138175
ENSMUST00000182226 ENSMUSP00000138312
ENSMUST00000183063
ENSMUST00000183197
ENSMUST00000183183
ENSMUST00000182731 ENSMUSP00000138238
ENSMUST00000183106
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0051497 negative regulation of stress fiber assembly
GO:0090005 negative regulation of establishment of protein localization to plasma membrane
Cellular Component
GO:0005737 cytoplasm
GO:0005925 focal adhesion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000131626
View Gene Order
ENSBTAG00000022188
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15293
Dopamine Neurotransmitter Release Cycle pathway
REACT_15309
Acetylcholine Neurotransmitter Release Cycle pathway
REACT_15425
Serotonin Neurotransmitter Release Cycle pathway
REACT_12591
Glutamate Neurotransmitter Release Cycle pathway
REACT_15418
Norepinephrine Neurotransmitter Release Cycle pathway
REACT_13685
Neuronal System pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_13723
Neurotransmitter Release Cycle pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B2RXW8
UniProt Splice Variant
Entrez Gene 233977
UniGene Mm.272809 Mm.400642
RefSeq NM_001033319 XM_006508606 NM_001195086 XM_006508598 XM_006508609 XM_006508610
OMIM
CCDS CCDS52464 CCDS59738
HPRD
IMGT
MGI ID MGI:1924750
MGI Symbol Ppfia1
EMBL AC140268 AC153792 BC158007
GenPept AAI58008
RNA Seq Atlas 233977

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca