Version 5.4
Homo sapiens Gene: PPFIA1
Summary
InnateDB Gene IDBG-62169.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPFIA1
Gene Name protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
Synonyms LIP.1; LIP1; LIPRIN
Species Homo sapiens
Ensembl Gene ENSG00000131626
Encoded Proteins
IDBP-62171
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
IDBP-62177
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
IDBP-590307
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
IDBP-591202
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
IDBP-598067
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
IDBP-589231
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
IDBP-597723
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
IDBP-597171
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
IDBP-591726
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
IDBP-586874
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
IDBP-592726
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
IDBP-597670
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
IDBP-584763
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
IDBP-585298
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
IDBP-598045
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:70270700-70384403
Strand Forward strand
Band q13.3
Transcripts
ENST00000253925 ENSP00000253925
ENST00000389547 ENSP00000374198
ENST00000532504 ENSP00000433619
ENST00000530746 ENSP00000432722
ENST00000532024 ENSP00000432065
ENST00000526262 ENSP00000435752
ENST00000530932
ENST00000525530
ENST00000532443
ENST00000530798 ENSP00000433114
ENST00000526369 ENSP00000437024
ENST00000526347 ENSP00000431692
ENST00000530294 ENSP00000431828
ENST00000526074
ENST00000528284
ENST00000528750 ENSP00000434445
ENST00000533894 ENSP00000432913
ENST00000530390 ENSP00000435978
ENST00000527612
ENST00000532793
ENST00000530548
ENST00000525922 ENSP00000436234
ENST00000531657
ENST00000528853 ENSP00000434692
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 50 [view]
Protein-Protein 49 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0007160 cell-matrix adhesion
GO:0007165 signal transduction
GO:0051497 negative regulation of stress fiber assembly
GO:0090005 negative regulation of establishment of protein localization to plasma membrane
Cellular Component
GO:0005737 cytoplasm
GO:0005925 focal adhesion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037519
View Gene Order
ENSBTAG00000022188
Not yet available
Pathways
NETPATH
REACTOME
REACT_15293
Dopamine Neurotransmitter Release Cycle pathway
REACT_15309
Acetylcholine Neurotransmitter Release Cycle pathway
REACT_15425
Serotonin Neurotransmitter Release Cycle pathway
REACT_12591
Glutamate Neurotransmitter Release Cycle pathway
REACT_15418
Norepinephrine Neurotransmitter Release Cycle pathway
REACT_13685
Neuronal System pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_13723
Neurotransmitter Release Cycle pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.530749 Hs.680215
RefSeq NM_003626 NM_177423 XM_006718718 XM_006718723
HUGO
OMIM
CCDS CCDS31627 CCDS31628
HPRD 11451
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca