Version 5.4
Homo sapiens Gene: CLPP
Summary
InnateDB Gene IDBG-21297.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLPP
Gene Name ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)
Synonyms PRLTS3
Species Homo sapiens
Ensembl Gene ENSG00000125656
Encoded Proteins
IDBP-21299
ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)
IDBP-760273
IDBP-766235
IDBP-765428
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:6361452-6368908
Strand Forward strand
Band p13.3
Transcripts
ENST00000245816 ENSP00000245816
ENST00000594780
ENST00000596149 ENSP00000472227
ENST00000596070
ENST00000596605 ENSP00000469124
ENST00000597326 ENSP00000470098
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0042802 identical protein binding
Biological Process
GO:0006508 proteolysis
GO:0051260 protein homooligomerization
GO:0051603 proteolysis involved in cellular protein catabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0009368 endopeptidase Clp complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002660
View Gene Order
ENSBTAG00000014712
Not yet available
Cross-References
SwissProt
TrEMBL M0QXE9
UniProt Splice Variant
Entrez Gene 8192
UniGene
RefSeq NM_006012
HUGO HGNC:2084
OMIM 601119
CCDS CCDS12162
HPRD 03074
IMGT
EMBL AC011491
GenPept
RNA Seq Atlas 8192

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca