Version 5.4
Mus musculus Gene: Map3k14
Summary
InnateDB Gene IDBG-213002.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Map3k14
Gene Name mitogen-activated protein kinase kinase kinase 14
Synonyms aly; Nik
Species Mus musculus
Ensembl Gene ENSMUSG00000020941
Encoded Proteins
IDBP-213004
mitogen-activated protein kinase kinase kinase 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:103219762-103267472
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000021324 ENSMUSP00000021324
ENSMUST00000146163
ENSMUST00000152300
ENSMUST00000152677
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004704 NF-kappaB-inducing kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0006468 protein phosphorylation
GO:0006955 immune response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0038061 NIK/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0071260 cellular response to mechanical stimulus
Cellular Component
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
mmu04660
T cell receptor signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
mmu04210
Apoptosis pathway
mmu04672
Intestinal immune network for IgA production pathway
mmu04380
Osteoclast differentiation pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
PDGF signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.158981
RefSeq NM_016896
OMIM
CCDS CCDS25516
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca