InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Map3k14

Summary

InnateDB Protein

IDBP-213004.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map3k14

Protein Name

mitogen-activated protein kinase kinase kinase 14

Synonyms

aly; Nik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021324

InnateDB Gene

IDBG-213002 (Map3k14)

Protein Structure

UniProt Annotation

Function

Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non- canonical pathway. Could act in a receptor-selective manner. {ECO:0000269PubMed:11239468}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004704	NF-kappaB-inducing kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation
GO:0006955	immune response
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0038061	NIK/NF-kappaB signaling
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0071260	cellular response to mechanical stimulus

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1858204

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR017425 Mitogen-activated protein (MAP) kinase kinase kinase 14
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

PIRSF038175

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References