InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kcnb1

Summary

InnateDB Gene

IDBG-213015.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnb1

Gene Name

potassium voltage gated channel, Shab-related subfamily, member 1

Synonyms

Kcr1-1; Kv2.1; Shab

Species

Mus musculus

Ensembl Gene

ENSMUSG00000050556

Encoded Proteins

IDBP-213017

potassium voltage gated channel, Shab-related subfamily, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158445:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:167103378-167190155

Strand

Reverse strand

Band

Transcripts

ENSMUST00000059826	ENSMUSP00000057981
ENSMUST00000131267

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding
GO:0015271	outward rectifier potassium channel activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0034765	regulation of ion transmembrane transport
GO:0051259	protein oligomerization
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0030425	dendrite
GO:0032590	dendrite membrane
GO:0032809	neuronal cell body membrane
GO:0043025	neuronal cell body
GO:0045211	postsynaptic membrane