InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KCNB1

Summary

InnateDB Gene

IDBG-80501.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNB1

Gene Name

potassium voltage-gated channel, Shab-related subfamily, member 1

Synonyms

DRK1; h-DRK1; KV2.1

Species

Homo sapiens

Ensembl Gene

ENSG00000158445

Encoded Proteins

IDBP-80503

potassium voltage-gated channel, Shab-related subfamily, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:49363877-49482647

Strand

Reverse strand

Band

q13.13

Transcripts

ENST00000371741

ENSP00000360806

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding
GO:0015271	outward rectifier potassium channel activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0034765	regulation of ion transmembrane transport
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion
GO:0051259	protein oligomerization
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0030425	dendrite
GO:0032590	dendrite membrane
GO:0032809	neuronal cell body membrane
GO:0043025	neuronal cell body
GO:0045211	postsynaptic membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000050556

View Gene Order

ENSBTAG00000027320

Not yet available

Pathways

NETPATH

REACTOME

REACT_75770

Voltage gated Potassium channels pathway

REACT_18274

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway

REACT_18325

Regulation of insulin secretion pathway

REACT_1505

Integration of energy metabolism pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

REACT_111217

Metabolism pathway

KEGG

hsa04742

Taste transduction pathway

INOH

PID NCI

Cross-References

SwissProt

Q14721

TrEMBL

UniProt Splice Variant

Entrez Gene

3745

UniGene

Hs.596488 Hs.598736 Hs.84244

RefSeq

NM_004975 XM_006723784

HUGO

HGNC:6231

OMIM

600397

CCDS

CCDS13418

HPRD

IMGT

EMBL

AF026005 AL035685 L02840 X68302

GenPept

AAA36156 AAB88808 CAA48374 CAB89417

RNA Seq Atlas

3745