InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Wnt9b

Summary

InnateDB Gene

IDBG-213052.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wnt9b

Gene Name

wingless-type MMTV integration site 9B

Synonyms

clf; clf1; wnt-14b; wnt-15; Wnt14b; Wnt15

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018486

Encoded Proteins

IDBP-213054

wingless-type MMTV integration site 9B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23785285

[Homo sapiens] Secretion of WNT9B upon virus infection negatively regulates antiviral innate immunity.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158955:
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:103727364-103749821

Strand

Reverse strand

Band

Transcripts

ENSMUST00000018630

ENSMUSP00000018630

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding

Biological Process

GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001701	in utero embryonic development
GO:0001822	kidney development
GO:0001932	regulation of protein phosphorylation
GO:0003339	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0009267	cellular response to starvation
GO:0009786	regulation of asymmetric cell division
GO:0009887	organ morphogenesis
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0030539	male genitalia development
GO:0035150	regulation of tube size
GO:0043085	positive regulation of catalytic activity
GO:0045165	cell fate commitment
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048754	branching morphogenesis of an epithelial tube
GO:0060021	palate development
GO:0060070	canonical Wnt signaling pathway
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0060993	kidney morphogenesis
GO:0061038	uterus morphogenesis
GO:0072003	kidney rudiment formation
GO:0072038	mesenchymal stem cell maintenance involved in nephron morphogenesis
GO:0072044	collecting duct development
GO:0072046	establishment of planar polarity involved in nephron morphogenesis
GO:0072078	nephron tubule morphogenesis
GO:0072164	mesonephric tubule development
GO:0072170	metanephric tubule development
GO:0072174	metanephric tubule formation
GO:0072181	mesonephric duct formation