InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WNT9B

Summary

InnateDB Gene

IDBG-55716.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNT9B

Gene Name

wingless-type MMTV integration site family, member 9B

Synonyms

WNT14B; WNT15

Species

Homo sapiens

Ensembl Gene

ENSG00000158955

Encoded Proteins

IDBP-55720

wingless-type MMTV integration site family, member 9B

IDBP-243590

wingless-type MMTV integration site family, member 9B

IDBP-760128

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 23785285

Secretion of WNT9B upon virus infection negatively regulates antiviral innate immunity.

Entrez Gene

Summary

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:46833201-46886730

Strand

Forward strand

Band

q21.32

Transcripts

ENST00000290015	ENSP00000290015
ENST00000393461	ENSP00000377105
ENST00000575372	ENSP00000458192

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding

Biological Process

GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001701	in utero embryonic development
GO:0001822	kidney development
GO:0001932	regulation of protein phosphorylation
GO:0003339	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0009267	cellular response to starvation
GO:0009786	regulation of asymmetric cell division
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0030539	male genitalia development
GO:0032526	response to retinoic acid
GO:0035150	regulation of tube size
GO:0043085	positive regulation of catalytic activity
GO:0045087	innate immune response (InnateDB)
GO:0045165	cell fate commitment
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048754	branching morphogenesis of an epithelial tube
GO:0060021	palate development
GO:0060070	canonical Wnt signaling pathway
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0060993	kidney morphogenesis
GO:0061038	uterus morphogenesis
GO:0061303	cornea development in camera-type eye
GO:0071300	cellular response to retinoic acid
GO:0072003	kidney rudiment formation
GO:0072038	mesenchymal stem cell maintenance involved in nephron morphogenesis
GO:0072044	collecting duct development
GO:0072046	establishment of planar polarity involved in nephron morphogenesis
GO:0072078	nephron tubule morphogenesis
GO:0072164	mesonephric tubule development
GO:0072170	metanephric tubule development
GO:0072174	metanephric tubule formation
GO:0072181	mesonephric duct formation