InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mapt

Summary

InnateDB Gene

IDBG-213115.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mapt

Gene Name

microtubule-associated protein tau

Synonyms

AI413597; AW045860; Mtapt; Tau

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018411

Encoded Proteins

IDBP-213119

microtubule-associated protein tau

IDBP-267607

microtubule-associated protein tau

IDBP-267609

microtubule-associated protein tau

IDBP-267615

microtubule-associated protein tau

IDBP-267617

microtubule-associated protein tau

IDBP-533933

microtubule-associated protein tau

IDBP-541618

microtubule-associated protein tau

IDBP-532777

microtubule-associated protein tau

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186868:
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer\'s disease, Pick\'s disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:104231390-104332090

Strand

Forward strand

Band

Transcripts

ENSMUST00000100347	ENSMUSP00000097919
ENSMUST00000106993	ENSMUSP00000102606
ENSMUST00000106992	ENSMUSP00000102605
ENSMUST00000106989	ENSMUSP00000102602
ENSMUST00000106988	ENSMUSP00000102601
ENSMUST00000138384
ENSMUST00000145227	ENSMUSP00000114716
ENSMUST00000132977	ENSMUSP00000123260
ENSMUST00000146353
ENSMUST00000132245	ENSMUSP00000119145
ENSMUST00000144836
ENSMUST00000126820

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	3 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0015631	tubulin binding
GO:0017124	SH3 domain binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0034185	apolipoprotein binding
GO:0071813	lipoprotein particle binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0001764	neuron migration
GO:0007409	axonogenesis
GO:0007628	adult walking behavior
GO:0008088	axon cargo transport
GO:0010506	regulation of autophagy
GO:0031116	positive regulation of microtubule polymerization
GO:0032387	negative regulation of intracellular transport
GO:0045773	positive regulation of axon extension
GO:0047497	mitochondrion transport along microtubule
GO:0048675	axon extension
GO:0060632	regulation of microtubule-based movement

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0005930	axoneme
GO:0015630	microtubule cytoskeleton
GO:0030424	axon
GO:0030426	growth cone
GO:0034399	nuclear periphery
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0045298	tubulin complex