InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mapt

Summary

InnateDB Protein

IDBP-213119.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mapt

Protein Name

microtubule-associated protein tau

Synonyms

AI413597; AW045860; Mtapt; Tau;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000097919

InnateDB Gene

IDBG-213115 (Mapt)

Protein Structure

UniProt Annotation

Function

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Subcellular Localization

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.

Disease Associations

Note=May be involved in the pathogenesis of cytoplasmic inclusions (as Mallory bodies) in livers of mice chronically intoxicated with Griseofulvin or DDC (3,5-diethoxycarbonyl-2,4- dihydrocollidine), a model for human alcoholic hepatitis. Alteration of Tau (abnormal phosphorylation and cross-linking) could contribute to Mallory bodies formation and disturbance of microtubule function in alcoholic liver disease.

Tissue Specificity

Expressed in neurons and at a lower level in the liver and kidney. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	3 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0015631	tubulin binding
GO:0017124	SH3 domain binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0034185	apolipoprotein binding
GO:0071813	lipoprotein particle binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0001764	neuron migration
GO:0007409	axonogenesis
GO:0007628	adult walking behavior
GO:0008088	axon cargo transport
GO:0010506	regulation of autophagy
GO:0031116	positive regulation of microtubule polymerization
GO:0032387	negative regulation of intracellular transport
GO:0045773	positive regulation of axon extension
GO:0047497	mitochondrion transport along microtubule
GO:0048675	axon extension
GO:0060632	regulation of microtubule-based movement

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0005930	axoneme
GO:0015630	microtubule cytoskeleton
GO:0030424	axon
GO:0030426	growth cone
GO:0034399	nuclear periphery
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0045298	tubulin complex