Version 5.4
Mus musculus Gene: Dok5
Summary
InnateDB Gene IDBG-213259.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dok5
Gene Name docking protein 5
Synonyms 2700055C10Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000027560
Encoded Proteins
IDBP-213261
docking protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101134:
The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:170731807-170879769
Strand Forward strand
Band H3
Transcripts
ENSMUST00000029075 ENSMUSP00000029075
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005158 insulin receptor binding
Biological Process
GO:0000165 MAPK cascade
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 nervous system development
Cellular Component
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000101134
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
ret_pathway
Signaling events regulated by Ret tyrosine kinase
Cross-References
SwissProt Q91ZM9
TrEMBL
UniProt Splice Variant
Entrez Gene 76829
UniGene Mm.41633
RefSeq NM_001163686 NM_029761
OMIM
CCDS CCDS17125
HPRD
IMGT
MGI ID MGI:1924079
MGI Symbol Dok5
EMBL AF418208 AK012430 AK044148
GenPept AAL14627 BAB28233 BAC31799
RNA Seq Atlas 76829

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca