Version 5.4
Mus musculus Protein: Dok5
Summary
InnateDB Protein IDBP-213261.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dok5
Protein Name docking protein 5
Synonyms 2700055C10Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000029075
InnateDB Gene IDBG-213259 (Dok5)
Protein Structure
UniProt Annotation
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. {ECO:0000269PubMed:11470823}.
Subcellular Localization
Disease Associations
Tissue Specificity Specifically expressed in the brain, with a high specificity for neurons. {ECO:0000269PubMed:11470823}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005158 insulin receptor binding
Biological Process
GO:0000165 MAPK cascade
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 nervous system development
Cellular Component
Protein Structure and Domains
PDB ID MGI:1924079
InterPro IPR001849 Pleckstrin homology domain
IPR002404 Insulin receptor substrate-1, PTB
PFAM PF00169
PF02174
PRINTS PR00628
PIRSF
SMART SM00233
SM00310
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91ZM9
PhosphoSite PhosphoSite-Q91ZM9
TrEMBL
UniProt Splice Variant
Entrez Gene 76829
UniGene Mm.41633
RefSeq NP_084037
MGI ID
MGI Symbol Dok5
OMIM
CCDS CCDS17125
HPRD
IMGT
EMBL AF418208 AK012430 AK044148
GenPept AAL14627 BAB28233 BAC31799

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca