InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dcaf7

Summary

InnateDB Gene

IDBG-213333.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dcaf7

Gene Name

DDB1 and CUL4 associated factor 7

Synonyms

1700012F10Rik; 2610037L01Rik; C86529; HAN11; Wdr68

Species

Mus musculus

Ensembl Gene

ENSMUSG00000049354

Encoded Proteins

IDBP-213335

DDB1 and CUL4 associated factor 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136485:
This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signalling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signaling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:106036872-106059324

Strand

Forward strand

Band

Transcripts

ENSMUST00000058438	ENSMUSP00000058168
ENSMUST00000106891

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007275	multicellular organismal development
GO:0016567	protein ubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016363	nuclear matrix
GO:0043234	protein complex
GO:0080008	Cul4-RING E3 ubiquitin ligase complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000136485

View Gene Order

ENSBTAG00000003500

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

P61963

TrEMBL

Q80ZU1

UniProt Splice Variant

Entrez Gene

71833

UniGene

Mm.307455

RefSeq

NM_027946

OMIM

CCDS

CCDS25546

HPRD

IMGT

MGI ID

MGI:1919083

MGI Symbol

Dcaf7

EMBL

AK005902 AK047435 AK165674 BC048165 BC048722

GenPept

AAH48165 AAH48722 BAB24308 BAC33058 BAE38331

RNA Seq Atlas

71833