InnateDB Protein
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IDBP-213335.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Dcaf7
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Protein Name
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DDB1 and CUL4 associated factor 7
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Synonyms
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1700012F10Rik; 2610037L01Rik; C86529; HAN11; Wdr68;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000058168
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InnateDB Gene
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IDBG-213333 (Dcaf7)
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Protein Structure
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Function |
Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches. Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000305}. Nucleus {ECO:0000250}. Note=Overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
36 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1919083
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InterPro |
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
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PFAM |
PF00400
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PRINTS |
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PIRSF |
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SMART |
SM00320
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TIGRFAMs |
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Modification |
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SwissProt |
P61963
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PhosphoSite |
PhosphoSite-P61963
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TrEMBL |
Q80ZU1
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UniProt Splice Variant |
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Entrez Gene |
71833
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UniGene |
Mm.307455
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RefSeq |
NP_082222
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MGI ID |
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MGI Symbol |
Dcaf7
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OMIM |
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CCDS |
CCDS25546
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HPRD |
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IMGT |
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EMBL |
AK005902
AK047435
AK165674
BC048165
BC048722
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GenPept |
AAH48165
AAH48722
BAB24308
BAC33058
BAE38331
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