InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Adrm1

Summary

InnateDB Gene

IDBG-213772.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adrm1

Gene Name

adhesion regulating molecule 1

Synonyms

1110063P18Rik; 2510006J17Rik; AA408205; ARM-1; Arm1; AU043535; Gp110; Rpn13

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039041

Encoded Proteins

IDBP-213774

adhesion regulating molecule 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130706:
The protein encoded by this gene is an integral plasma membrane protein which promotes cell adhesion. The encoded protein is thought to undergo O-linked glycosylation. Expression of this gene has been shown to be induced by gamma interferon in some cancer cells. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:180171485-180176286

Strand

Forward strand

Band

Transcripts

ENSMUST00000061437	ENSMUSP00000050076
ENSMUST00000155357
ENSMUST00000128029
ENSMUST00000147341
ENSMUST00000152540
ENSMUST00000145230
ENSMUST00000147383
ENSMUST00000152850

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0001541	ovarian follicle development
GO:0007286	spermatid development
GO:0033081	regulation of T cell differentiation in thymus
GO:0042699	follicle-stimulating hormone signaling pathway
GO:0048477	oogenesis
GO:0048538	thymus development
GO:0060009	Sertoli cell development
GO:0060399	positive regulation of growth hormone receptor signaling pathway
GO:0060612	adipose tissue development
GO:0072520	seminiferous tubule development

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000130706

View Gene Order

ENSBTAG00000003058

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

deltanp63pathway

Validated transcriptional targets of deltaNp63 isoforms

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.379082

RefSeq

NM_019822 XM_006500680

OMIM

CCDS

CCDS17171

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas