InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Birc7

Summary

InnateDB Gene

IDBG-213920.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Birc7

Gene Name

baculoviral IAP repeat-containing 7 (livin)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038840

Encoded Proteins

IDBP-263615

baculoviral IAP repeat-containing 7 (livin)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101197:
The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:180929023-180934010

Strand

Forward strand

Band

Transcripts

ENSMUST00000108875	ENSMUSP00000104503
ENSMUST00000137859

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0006915	apoptotic process
GO:0010951	negative regulation of endopeptidase activity
GO:0016567	protein ubiquitination
GO:0042127	regulation of cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0070247	regulation of natural killer cell apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000101197

View Gene Order

ENSBTAG00000004911

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04120

Ubiquitin mediated proteolysis pathway

mmu05222

Small cell lung cancer pathway

mmu04210

Apoptosis pathway

mmu05200

Pathways in cancer pathway

mmu05145

Toxoplasmosis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04210

Apoptosis pathway

hsa04120

Ubiquitin mediated proteolysis pathway

hsa05222

Small cell lung cancer pathway

hsa05200

Pathways in cancer pathway

hsa05145

Toxoplasmosis pathway

INOH

PID NCI

Cross-References

SwissProt

A2AWP0

TrEMBL

UniProt Splice Variant

Entrez Gene

329581

UniGene

Mm.187879

RefSeq

NM_001163247 XM_006500665

OMIM

CCDS

CCDS50840

HPRD

IMGT

MGI ID

MGI:2676458

MGI Symbol

Birc7

EMBL

AL954707 BC107260 BC125013

GenPept

AAI07261 AAI25014 CAM22145

RNA Seq Atlas

329581