Version 5.4
Mus musculus Gene: Abca5
Summary
InnateDB Gene IDBG-213946.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Abca5
Gene Name ATP-binding cassette, sub-family A (ABC1), member 5
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000018800
Encoded Proteins
IDBP-213950
ATP-binding cassette, sub-family A (ABC1), member 5
IDBP-535686
ATP-binding cassette, sub-family A (ABC1), member 5
IDBP-532960
ATP-binding cassette, sub-family A (ABC1), member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154265:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:110269369-110337716
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000043961 ENSMUSP00000047927
ENSMUST00000124714 ENSMUSP00000120708
ENSMUST00000127318
ENSMUST00000134721 ENSMUSP00000118328
ENSMUST00000148984
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0006200 ATP catabolic process
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0033344 cholesterol efflux
GO:0034375 high-density lipoprotein particle remodeling
GO:0043691 reverse cholesterol transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
GO:0031902 late endosome membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000154265
View Gene Order
ENSBTAG00000002747
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu02010
ABC transporters pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa02010
ABC transporters pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.41942
RefSeq NM_147219 XM_006533065
OMIM
CCDS CCDS25591
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca