Version 5.4
Mus musculus Protein: Abca5
Summary
InnateDB Protein IDBP-213950.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Abca5
Protein Name ATP-binding cassette, sub-family A (ABC1), member 5
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000047927
InnateDB Gene IDBG-213946 (Abca5)
Protein Structure
UniProt Annotation
Function May play a role in the processing of autolysosomes. {ECO:0000269PubMed:15870284}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000269PubMed:15870284}; Multi-pass membrane protein {ECO:0000269PubMed:15870284}. Late endosome membrane {ECO:0000269PubMed:15870284}; Multi-pass membrane protein {ECO:0000269PubMed:15870284}.
Disease Associations
Tissue Specificity Expressed in cardiomyocytes, oligodendrocytes and astrocytes in brain, alveolar type 2 cells in lung and follicular cells in the thyroid gland (at protein level). Detected in brain, testis, lung, heart, liver, kidney, skeletal muscle and placenta. {ECO:0000269PubMed:12532264, ECO:0000269PubMed:15870284}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0006200 ATP catabolic process
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0033344 cholesterol efflux
GO:0034375 high-density lipoprotein particle remodeling
GO:0043691 reverse cholesterol transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
GO:0031902 late endosome membrane
Protein Structure and Domains
PDB ID MGI:2386607
InterPro IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00005
PRINTS
PIRSF
SMART SM00382
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K448
PhosphoSite PhosphoSite-Q8K448
TrEMBL A2AEP6
UniProt Splice Variant
Entrez Gene 217265
UniGene Mm.41942
RefSeq NP_671752
MGI ID
MGI Symbol Abca5
OMIM
CCDS CCDS25591
HPRD
IMGT
EMBL AB097675 AF491842 AK034961 AK047188 AK129463 AK138604 AK169879 AL603792 AL671964 BC064823
GenPept AAH64823 AAM90895 BAC28896 BAC32984 BAC66658 BAC98273 BAE23713 BAE41431

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca