InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Arfrp1

Summary

InnateDB Gene

IDBG-214083.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arfrp1

Gene Name

ADP-ribosylation factor related protein 1

Synonyms

1500006I01Rik; AI480700

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038671

Encoded Proteins

IDBP-263747

ADP-ribosylation factor related protein 1

IDBP-533302

ADP-ribosylation factor related protein 1

IDBP-626943

ADP-ribosylation factor related protein 1

IDBP-789587

ADP-ribosylation factor related protein 1

IDBP-789590

ADP-ribosylation factor related protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The gene encodes a membrane-associated GTPase that is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) genes. It plays an essential role in Golgi function controlling recruitment of GRIP domain proteins and ARL1 to the trans-Golgi and trans-Golgi to plasma membrane trafficking of cell surface proteins such as E-cadherin. Deletion of this gene in mice leads to embryonic lethality during early gastrulation, which is at least partly caused by the disruption of E-cadherin trafficking to the cell surface and therefore lack of sufficient cell-cell adhesion in the embryo. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:181357690-181365404

Strand

Reverse strand

Band

Transcripts

ENSMUST00000048269
ENSMUST00000108808	ENSMUSP00000104436
ENSMUST00000127988	ENSMUSP00000122066
ENSMUST00000152334
ENSMUST00000152580
ENSMUST00000130346
ENSMUST00000139368
ENSMUST00000145358
ENSMUST00000170190	ENSMUSP00000126387
ENSMUST00000185118	ENSMUSP00000139211
ENSMUST00000183499	ENSMUSP00000138941
ENSMUST00000184859

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0007369	gastrulation
GO:0015031	protein transport
GO:0034067	protein localization to Golgi apparatus
GO:0042147	retrograde transport, endosome to Golgi
GO:0043001	Golgi to plasma membrane protein transport

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000101246

View Gene Order

ENSBTAG00000007497

Not yet available

Cross-References

SwissProt

Q8BXL7

TrEMBL

E9PZK7 Q80SX7 V9GX20

UniProt Splice Variant

Entrez Gene

76688

UniGene

RefSeq

NM_001165991 NM_001165992 NM_001165995 NM_029702

OMIM

CCDS

CCDS17209 CCDS50853

HPRD

IMGT

MGI ID

MGI:1923938

MGI Symbol

Arfrp1

EMBL

AJ413952 AJ413953 AK005174 AK044759 AL928965 BC010713 BC046782 BC046786

GenPept

AAH10713 AAH46782 AAH46786 BAB23861 BAC32069 CAC88691 CAC88692

RNA Seq Atlas

76688