Version 5.4
Homo sapiens Gene: ARFRP1
Summary
InnateDB Gene IDBG-87087.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARFRP1
Gene Name ADP-ribosylation factor related protein 1
Synonyms ARL18; ARP; Arp1
Species Homo sapiens
Ensembl Gene ENSG00000101246
Encoded Proteins
IDBP-811332
ADP-ribosylation factor related protein 1
IDBP-811338
ADP-ribosylation factor related protein 1
IDBP-811343
ADP-ribosylation factor related protein 1
IDBP-811344
ADP-ribosylation factor related protein 1
IDBP-811352
ADP-ribosylation factor related protein 1
IDBP-811356
ADP-ribosylation factor related protein 1
IDBP-811359
ADP-ribosylation factor related protein 1
IDBP-811360
ADP-ribosylation factor related protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a membrane-associated GTP-ase which localizes to the plasma membrane and is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins. This gene plays a role in membrane trafficking between the trans-Golgi network and endosomes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:63698642-63708025
Strand Reverse strand
Band q13.33
Transcripts
ENST00000424545
ENST00000612256 ENSP00000484109
ENST00000610414
ENST00000612772
ENST00000618838 ENSP00000479616
ENST00000612157 ENSP00000479058
ENST00000618568 ENSP00000481446
ENST00000610774
ENST00000609188
ENST00000607873 ENSP00000476756
ENST00000609537
ENST00000614942 ENSP00000483130
ENST00000619493 ENSP00000479940
ENST00000622789 ENSP00000483486
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007369 gastrulation
GO:0015031 protein transport
GO:0034067 protein localization to Golgi apparatus
GO:0042147 retrograde transport, endosome to Golgi
GO:0043001 Golgi to plasma membrane protein transport
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038671
View Gene Order
ENSBTAG00000007497
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 10139
UniGene
RefSeq NM_001134758 NM_001267544 NM_001267549 NM_001267545 NM_001267546 NM_001267547 NM_001267548 NM_003224
HUGO HGNC:662
OMIM 604699
CCDS CCDS46630 CCDS13533 CCDS68172 CCDS68173
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 10139

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca