InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nt5c

Summary

InnateDB Gene

IDBG-214315.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nt5c

Gene Name

5',3'-nucleotidase, cytosolic

Synonyms

Dnt; Dnt1; Umph-2; Umph2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020736

Encoded Proteins

IDBP-214317

5',3'-nucleotidase, cytosolic

IDBP-268583

5',3'-nucleotidase, cytosolic

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125458:
This gene encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2'(3')-dNTP and ribonucleotides, but not 5' ribonucleotides. Of the different forms of nucleotidases characterized, this enzyme is unique in its preference for 5'-dNTP. It may be one of the enzymes involved in regulating the size of dNTP pools in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:115490420-115491862

Strand

Reverse strand

Band

Transcripts

ENSMUST00000021082	ENSMUSP00000021082
ENSMUST00000106530	ENSMUSP00000102140
ENSMUST00000124778
ENSMUST00000125940
ENSMUST00000130668

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008252	nucleotidase activity
GO:0008253	5'-nucleotidase activity
GO:0016791	phosphatase activity
GO:0019103	pyrimidine nucleotide binding
GO:0046872	metal ion binding