Version 5.4
Mus musculus Protein: Nt5c
Summary
InnateDB Protein IDBP-214317.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nt5c
Protein Name 5',3'-nucleotidase, cytosolic
Synonyms Dnt; Dnt1; Umph-2; Umph2;
Species Mus musculus
Ensembl Protein ENSMUSP00000021082
InnateDB Gene IDBG-214315 (Nt5c)
Protein Structure
UniProt Annotation
Function Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. {ECO:0000269PubMed:10681516}.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008252 nucleotidase activity
GO:0008253 5'-nucleotidase activity
GO:0016791 phosphatase activity
GO:0019103 pyrimidine nucleotide binding
GO:0046872 metal ion binding
Biological Process
GO:0009223 pyrimidine deoxyribonucleotide catabolic process
GO:0009264 deoxyribonucleotide catabolic process
GO:0016311 dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1354954
InterPro IPR010708 5\'(3\')-deoxyribonucleotidase
IPR023214 HAD-like domain
PFAM PF06941
PF00702
PF08282
PF13419
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JM14
PhosphoSite PhosphoSite-Q9JM14
TrEMBL
UniProt Splice Variant
Entrez Gene 50773
UniGene Mm.390379
RefSeq NP_056622
MGI ID 2JAR
MGI Symbol Nt5c
OMIM
CCDS CCDS25637
HPRD
IMGT
EMBL AF078840 AK007418 BC024368 BK000208
GenPept AAF36421 AAH24368 BAB25027 DAA00069

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca