Version 5.4
Mus musculus Gene: Ccdc40
Summary
InnateDB Gene IDBG-214677.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccdc40
Gene Name coiled-coil domain containing 40
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000039963
Encoded Proteins
IDBP-214679
coiled-coil domain containing 40
IDBP-214685
coiled-coil domain containing 40
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141519:
This gene encodes a protein that is necessary for motile cilia function. It functions in correct left-right axis formation by regulating the assembly of the inner dynein arm and the dynein regulatory complexes, which control ciliary beat. Mutations in this gene cause ciliary dyskinesia type 15, a disorder due to defects in cilia motility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:119228572-119265236
Strand Forward strand
Band E2
Transcripts
ENSMUST00000035935 ENSMUSP00000039463
ENSMUST00000053440 ENSMUSP00000062198
ENSMUST00000150358
ENSMUST00000147037
ENSMUST00000143066
ENSMUST00000133788
ENSMUST00000126652
ENSMUST00000155683
ENSMUST00000125724
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0001947 heart looping
GO:0003341 cilium movement
GO:0003351 epithelial cilium movement
GO:0003356 regulation of cilium beat frequency
GO:0030324 lung development
GO:0035469 determination of pancreatic left/right asymmetry
GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry
GO:0070286 axonemal dynein complex assembly
GO:0071907 determination of digestive tract left/right asymmetry
GO:0071910 determination of liver left/right asymmetry
Cellular Component
GO:0005737 cytoplasm
GO:0005929 cilium
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000141519
View Gene Order
ENSBTAG00000016017
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.189885 Mm.488515
RefSeq NM_175430 XM_006532698 XM_006532699 XM_006532700
OMIM
CCDS CCDS25712
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca