Version 5.4
Mus musculus Protein: Ccdc40
Summary
InnateDB Protein IDBP-214679.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccdc40
Protein Name coiled-coil domain containing 40
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000039463
InnateDB Gene IDBG-214677 (Ccdc40)
Protein Structure
UniProt Annotation
Function Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:21131972}. Cell projection, cilium {ECO:0000269PubMed:21131972}. Note=Localizes to cytoplasm and motile cilium.
Disease Associations
Tissue Specificity Specifically expressed in the embryonic node and midline. {ECO:0000269PubMed:21131972}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0001947 heart looping
GO:0003341 cilium movement
GO:0003351 epithelial cilium movement
GO:0003356 regulation of cilium beat frequency
GO:0030324 lung development
GO:0035469 determination of pancreatic left/right asymmetry
GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry
GO:0070286 axonemal dynein complex assembly
GO:0071907 determination of digestive tract left/right asymmetry
GO:0071910 determination of liver left/right asymmetry
Cellular Component
GO:0005737 cytoplasm
GO:0005929 cilium
Protein Structure and Domains
PDB ID MGI:2443893
InterPro IPR013956 E3 ubiquitin ligase, BRE1
PFAM PF08647
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BI79
PhosphoSite PhosphoSite-Q8BI79
TrEMBL Q8BI54
UniProt Splice Variant
Entrez Gene 207607
UniGene Mm.488515
RefSeq NP_780639
MGI ID
MGI Symbol Ccdc40
OMIM
CCDS CCDS25712
HPRD
IMGT
EMBL AK046971 AK054172 AK077170 AL672140 BC085159
GenPept AAH85159 BAC32932 BAC35680 BAC36659 CAM15000 CAM15001

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca