Version 5.4
Mus musculus Gene: Aatk
Summary
InnateDB Gene IDBG-214739.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aatk
Gene Name apoptosis-associated tyrosine kinase
Synonyms AATYK; aatyk1; mKIAA0641
Species Mus musculus
Ensembl Gene ENSMUSG00000025375
Encoded Proteins
IDBP-214743
apoptosis-associated tyrosine kinase
IDBP-214745
apoptosis-associated tyrosine kinase
IDBP-214747
apoptosis-associated tyrosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181409:
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:120007313-120047167
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000103020 ENSMUSP00000099309
ENSMUST00000064307 ENSMUSP00000067181
ENSMUST00000103019 ENSMUSP00000099308
ENSMUST00000150730
ENSMUST00000142959
ENSMUST00000136386
ENSMUST00000132575
ENSMUST00000128836
ENSMUST00000134319
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007420 brain development
GO:0030517 negative regulation of axon extension
GO:0032482 Rab protein signal transduction
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0046777 protein autophosphorylation
GO:0051402 neuron apoptotic process
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0044295 axonal growth cone
GO:0048471 perinuclear region of cytoplasm
GO:0055037 recycling endosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000181409
View Gene Order
ENSBTAG00000019049
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.488770 Mm.6826
RefSeq NM_001198785 NM_001198787 NM_007377
OMIM
CCDS CCDS25725 CCDS56826
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca