InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rac3

Summary

InnateDB Gene

IDBG-214890.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rac3

Gene Name

RAS-related C3 botulinum substrate 3

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018012

Encoded Proteins

IDBP-214892

RAS-related C3 botulinum substrate 3

IDBP-537510

RAS-related C3 botulinum substrate 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169750:
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:120721470-120723969

Strand

Forward strand

Band

Transcripts

ENSMUST00000018156	ENSMUSP00000018156
ENSMUST00000142229	ENSMUSP00000119523
ENSMUST00000134322

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0030031	cell projection assembly
GO:0030036	actin cytoskeleton organization
GO:0031175	neuron projection development
GO:0033630	positive regulation of cell adhesion mediated by integrin
GO:0050885	neuromuscular process controlling balance
GO:0050905	neuromuscular process
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0030426	growth cone
GO:0031941	filamentous actin
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0048471	perinuclear region of cytoplasm
GO:0071944	cell periphery