InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAC3

Summary

InnateDB Gene

IDBG-73067.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAC3

Gene Name

ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000169750

Encoded Proteins

IDBP-73069

ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)

IDBP-759384

IDBP-757852

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:82031624-82034204

Strand

Forward strand

Band

q25.3

Transcripts

ENST00000306897	ENSP00000304283
ENST00000584341	ENSP00000462421
ENST00000585014
ENST00000580965	ENSP00000463590

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0030031	cell projection assembly
GO:0030036	actin cytoskeleton organization
GO:0031175	neuron projection development
GO:0033630	positive regulation of cell adhesion mediated by integrin
GO:0035556	intracellular signal transduction
GO:0050885	neuromuscular process controlling balance
GO:0050905	neuromuscular process
GO:0051056	regulation of small GTPase mediated signal transduction
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0030426	growth cone
GO:0031941	filamentous actin
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0048471	perinuclear region of cytoplasm
GO:0071944	cell periphery

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000018012

View Gene Order

Pathways

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

REACT_11051

Rho GTPase cycle pathway

REACT_172581

PCP/CE pathway pathway

REACT_172694

beta-catenin independent WNT signaling pathway

REACT_11045

Signaling by Wnt pathway

REACT_11044

Signaling by Rho GTPases pathway

REACT_111102

Signal Transduction pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04370

VEGF signaling pathway pathway

hsa04664

Fc epsilon RI signaling pathway pathway

hsa05210

Colorectal cancer pathway

hsa04310

Wnt signaling pathway pathway

hsa04010

MAPK signaling pathway pathway

hsa04360

Axon guidance pathway

hsa04520

Adherens junction pathway

hsa04662

B cell receptor signaling pathway pathway

hsa04510

Focal adhesion pathway

hsa04650

Natural killer cell mediated cytotoxicity pathway

hsa05212

Pancreatic cancer pathway

hsa05200

Pathways in cancer pathway

hsa05416

Viral myocarditis pathway

INOH

INOH website

CD4 T cell receptor signaling pathway

INOH website

HGF signaling pathway pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_005052 XM_005256390

HUGO

OMIM

CCDS

CCDS11798

HPRD

03629

IMGT

EMBL

GenPept

RNA Seq Atlas