Version 5.4
Homo sapiens Gene: DHX33
Summary
InnateDB Gene IDBG-21550.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DHX33
Gene Name DEAH (Asp-Glu-Ala-His) box polypeptide 33
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000005100
Encoded Proteins
IDBP-21554
DEAH (Asp-Glu-Ala-His) box polypeptide 33
IDBP-363987
DEAH (Asp-Glu-Ala-His) box polypeptide 33
IDBP-760300
IDBP-759244
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25816776
RNA cleavage products, catalyzed by RNASEL, bind to DHX33 to facilitate the formation of a complex with MAVS and NLRP3 during viral infection.
Entrez Gene
Summary This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:5440912-5469060
Strand Reverse strand
Band p13.2
Transcripts
ENST00000225296 ENSP00000225296
ENST00000433302 ENSP00000413779
ENST00000572490 ENSP00000458925
ENST00000575153
ENST00000574023 ENSP00000458203
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000182 rDNA binding
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0033613 activating transcription factor binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006200 ATP catabolic process
GO:0008152 metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045943 positive regulation of transcription from RNA polymerase I promoter
Cellular Component
GO:0005654 nucleoplasm
GO:0005730 nucleolus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040620
View Gene Order
ENSBTAG00000032083
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.250456 Hs.605789 Hs.708994
RefSeq NM_001199699 NM_020162
HUGO
OMIM
CCDS CCDS11072
HPRD 13143
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca