InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DHX33

Summary

InnateDB Protein

IDBP-21554.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHX33

Protein Name

DEAH (Asp-Glu-Ala-His) box polypeptide 33

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000225296

InnateDB Gene

IDBG-21550 (DHX33)

Protein Structure

UniProt Annotation

Function

Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. Important element of nucleolar organization. {ECO:0000269PubMed:21930779}.

Subcellular Localization

Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Predominantly in the nucleolus. During mitosis, localizes with the nucleolar organizing regions.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000182	rDNA binding
GO:0003676	nucleic acid binding
GO:0004386	helicase activity
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0033613	activating transcription factor binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045943	positive regulation of transcription from RNA polymerase I promoter

Cellular Component

GO:0005654	nucleoplasm
GO:0005730	nucleolus

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR007502 Helicase-associated domain
IPR011545 DEAD/DEAH box helicase domain
IPR011709 Domain of unknown function DUF1605
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF04408
PF00270
PF07717

PRINTS

PIRSF

SMART

SM00490
SM00847
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9H6R0