Version 5.4
Homo sapiens Gene: DENND1C
Summary
InnateDB Gene IDBG-21573.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DENND1C
Gene Name DENN/MADD domain containing 1C
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000205744
Encoded Proteins
IDBP-21575
DENN/MADD domain containing 1C
IDBP-587702
DENN/MADD domain containing 1C
IDBP-765557
IDBP-763679
IDBP-762539
IDBP-762596
IDBP-762297
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1C, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:6467207-6482557
Strand Reverse strand
Band p13.3
Transcripts
ENST00000381480 ENSP00000370889
ENST00000543576 ENSP00000437805
ENST00000590818
ENST00000590867 ENSP00000465675
ENST00000591030
ENST00000590473 ENSP00000466583
ENST00000591795
ENST00000590173 ENSP00000467008
ENST00000588421 ENSP00000466394
ENST00000588988
ENST00000586046 ENSP00000466334
ENST00000592543
ENST00000590444
ENST00000589491
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0017112 Rab guanyl-nucleotide exchange factor activity
Biological Process
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0005829 cytosol
GO:0030136 clathrin-coated vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002668
View Gene Order
ENSBTAG00000031809
Not yet available
Cross-References
SwissProt
TrEMBL K7EM80 K7EMN9 K7ENM0
UniProt Splice Variant
Entrez Gene 79958
UniGene Hs.236449
RefSeq NM_001290331 NM_024898 XM_006722906
HUGO HGNC:26225
OMIM 613634
CCDS CCDS45938
HPRD 13304
IMGT
EMBL AC010503
GenPept
RNA Seq Atlas 79958

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca