Version 5.4
Homo sapiens Protein: DENND1C
Summary
InnateDB Protein IDBP-21575.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DENND1C
Protein Name DENN/MADD domain containing 1C
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000370889
InnateDB Gene IDBG-21573 (DENND1C)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269PubMed:20154091, ECO:0000269PubMed:20937701}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0017112 Rab guanyl-nucleotide exchange factor activity
Biological Process
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0005829 cytosol
GO:0030136 clathrin-coated vesicle
Protein Structure and Domains
PDB ID
InterPro IPR001194 DENN domain
IPR005112 dDENN domain
IPR005113 uDENN domain
PFAM PF02141
PF03455
PF03456
PRINTS
PIRSF
SMART SM00799
SM00801
SM00800
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IV53
PhosphoSite PhosphoSite-Q8IV53
TrEMBL K7ENM0
UniProt Splice Variant
Entrez Gene 79958
UniGene Hs.236449
RefSeq NP_079174
HUGO HGNC:26225
OMIM 613634
CCDS CCDS45938
HPRD 13304
IMGT
EMBL AC010503 AK026410 AK055820 AK303226 AL834293 BC033437 BK006959 CH471139
GenPept AAH33437 BAB15475 BAG51578 BAG64313 CAD38966 DAA12501 EAW69080 EAW69082

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca