Version 5.4
Homo sapiens Gene: XRCC3
Summary
InnateDB Gene IDBG-22058.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XRCC3
Gene Name X-ray repair complementing defective repair in Chinese hamster cells 3
Synonyms CMM6
Species Homo sapiens
Ensembl Gene ENSG00000126215
Encoded Proteins
IDBP-22060
X-ray repair complementing defective repair in Chinese hamster cells 3
IDBP-595201
X-ray repair complementing defective repair in Chinese hamster cells 3
IDBP-600257
X-ray repair complementing defective repair in Chinese hamster cells 3
IDBP-596941
X-ray repair complementing defective repair in Chinese hamster cells 3
IDBP-586468
X-ray repair complementing defective repair in Chinese hamster cells 3
IDBP-808066
X-ray repair complementing defective repair in Chinese hamster cells 3
IDBP-586731
X-ray repair complementing defective repair in Chinese hamster cells 3
IDBP-585863
X-ray repair complementing defective repair in Chinese hamster cells 3
IDBP-599698
X-ray repair complementing defective repair in Chinese hamster cells 3
IDBP-591283
X-ray repair complementing defective repair in Chinese hamster cells 3
IDBP-603612
X-ray repair complementing defective repair in Chinese hamster cells 3
IDBP-587365
X-ray repair complementing defective repair in Chinese hamster cells 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:103697609-103715504
Strand Reverse strand
Band q32.33
Transcripts
ENST00000352127 ENSP00000343392
ENST00000554913 ENSP00000451362
ENST00000554811
ENST00000553264 ENSP00000451974
ENST00000555055 ENSP00000452598
ENST00000554974 ENSP00000451361
ENST00000554774
ENST00000555451
ENST00000555832
ENST00000553807
ENST00000557439 ENSP00000473569
ENST00000553361 ENSP00000451118
ENST00000556980 ENSP00000451252
ENST00000555964 ENSP00000451173
ENST00000555231
ENST00000556682 ENSP00000452389
ENST00000553332 ENSP00000450780
ENST00000554170 ENSP00000450738
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000400 four-way junction DNA binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 DNA-dependent ATPase activity
GO:0008821 crossover junction endodeoxyribonuclease activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006200 ATP catabolic process
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0010033 response to organic substance
GO:0010824 regulation of centrosome duplication
GO:0071140 resolution of mitotic recombination intermediates
GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint
Cellular Component
GO:0005634 nucleus
GO:0005657 replication fork
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0033065 Rad51C-XRCC3 complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021287
View Gene Order
ENSBTAG00000009966
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03440
Homologous recombination pathway
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.592325 Hs.733412
RefSeq NM_001100118 NM_001100119 NM_005432 XM_005268046
HUGO
OMIM
CCDS CCDS9984
HPRD 07201
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca