Homo sapiens Gene: RPL15
Summary
InnateDB Gene IDBG-22156.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol RPL15
Gene Name ribosomal protein L15
Synonyms EC45; L15; RPL10; RPLY10; RPYL10;
Species Homo sapiens
Ensembl Gene ENSG00000174748
Encoded Proteins
ribosomal protein L15
ribosomal protein L15
ribosomal protein L15
ribosomal protein L15
ribosomal protein L15
ribosomal protein L15
ribosomal protein L15
ribosomal protein L15
ribosomal protein L15
ribosomal protein L15
Protein Structure
Entrez Gene
Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15E family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Although this gene has been referred to as RPL10, its official symbol is RPL15. This gene has been shown to be overexpressed in some esophageal tumors compared to normal matched tissues. Alternate splicing results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:23958036-23965183
Strand Forward strand
Band p24.2
Transcripts
ENST00000354811 ENSP00000346867
ENST00000307839 ENSP00000309334
ENST00000422218 ENSP00000387925
ENST00000434031 ENSP00000405590
ENST00000413699 ENSP00000416692
ENST00000412097 ENSP00000411176
ENST00000435882 ENSP00000390193
ENST00000415719 ENSP00000388529
ENST00000456530 ENSP00000398788
ENST00000436146 ENSP00000408243
ENST00000490223
ENST00000465786
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 124 experimentally validated interaction(s) in this database.
Experimentally validated
Total 124 [view]
Protein-Protein 123 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0016032 viral reproduction
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019058 viral infectious cycle
GO:0019083 viral transcription
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Nonsense Mediated Decay Independent of the Exon Junction Complex pathway
Nonsense Mediated Decay Enhanced by the Exon Junction Complex pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Formation of a pool of free 40S subunits pathway
Eukaryotic Translation Termination pathway
Peptide chain elongation pathway
SRP-dependent cotranslational protein targeting to membrane pathway
Viral mRNA Translation pathway
KEGG
Ribosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P61313
TrEMBL E7ENU7 E7EQV9 E7ERA2 E7EX53 Q642I1 Q76N55
UniProt Splice Variant
Entrez Gene 6138
UniGene Hs.381219 Hs.630818 Hs.742264
RefSeq NM_001253379 NM_001253380 NM_001253382 NM_001253383 NM_001253384 NM_002948
HUGO 10306
OMIM 604174
CCDS CCDS2640
HPRD 16043
IMGT
EMBL AB007173 AB061823 AC124914 AF279903 AF283772 AK290694 AK292000 AY347528 BC014837 BC068198 BC070328 BC071672 BC081565 BT019672 CH471055 L25899
GenPept AAA36583 AAG15591 AAG44837 AAH14837 AAH68198 AAH70328 AAH71672 AAH81565 AAQ24859 AAV38478 BAA25833 BAB79461 BAF83383 BAF84689 EAW64338
ImmGen RPL15 (murine)
RNA Seq Atlas 6138