Version 5.4
Homo sapiens Gene: XPO6
Summary
InnateDB Gene IDBG-22210.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XPO6
Gene Name exportin 6
Synonyms EXP6; RANBP20
Species Homo sapiens
Ensembl Gene ENSG00000169180
Encoded Proteins
IDBP-22212
exportin 6
IDBP-748149
IDBP-749387
IDBP-752821
IDBP-753983
IDBP-749116
IDBP-751797
IDBP-752300
IDBP-751150
IDBP-751716
IDBP-751932
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:28097979-28211920
Strand Reverse strand
Band p12.1
Transcripts
ENST00000304658 ENSP00000302790
ENST00000569216
ENST00000567038
ENST00000570007
ENST00000564905 ENSP00000455310
ENST00000573275 ENSP00000458314
ENST00000569973
ENST00000570033 ENSP00000456066
ENST00000564337
ENST00000573645
ENST00000569315 ENSP00000454586
ENST00000566073 ENSP00000456273
ENST00000567842
ENST00000563138
ENST00000565698 ENSP00000457341
ENST00000569951 ENSP00000457742
ENST00000565284
ENST00000562408
ENST00000570294
ENST00000568065 ENSP00000456422
ENST00000574435 ENSP00000459736
ENST00000566175 ENSP00000459591
ENST00000561488
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008536 Ran GTPase binding
GO:0008565 protein transporter activity
Biological Process
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000131
View Gene Order
ENSBTAG00000010309
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.460468
RefSeq NM_001270940 NM_015171 XM_005255195 XM_005255197 XM_005255199
HUGO
OMIM
CCDS CCDS42135 CCDS59266
HPRD 10525
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca