Version 5.4
Homo sapiens Protein: XPO6
Summary
InnateDB Protein IDBP-22212.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XPO6
Protein Name exportin 6
Synonyms EXP6; RANBP20;
Species Homo sapiens
Ensembl Protein ENSP00000302790
InnateDB Gene IDBG-22210 (XPO6)
Protein Structure
UniProt Annotation
Function Mediates the nuclear export of actin and profilin-actin complexes in somatic cells. {ECO:0000269PubMed:14592989}.
Subcellular Localization Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008536 Ran GTPase binding
GO:0008565 protein transporter activity
Biological Process
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001494 Importin-beta, N-terminal domain
IPR013598 Exportin-1/Importin-beta-like
IPR016024 Armadillo-type fold
PFAM PF03810
PF08389
PRINTS
PIRSF
SMART SM00913
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96QU8
PhosphoSite PhosphoSite-Q96QU8
TrEMBL H3BUP8
UniProt Splice Variant
Entrez Gene 23214
UniGene Hs.460468
RefSeq NP_055986
HUGO HGNC:19733
OMIM 608411
CCDS CCDS42135
HPRD 10525
IMGT
EMBL AB002368 AC136611 AK223043 AY026388 BC004403 BC014071 BC078674 BC108286 BC130304 CH471145
GenPept AAH04403 AAH14071 AAH78674 AAI08287 AAI30305 AAK01471 BAA20825 BAD96763 EAW55736 EAW55738 EAW55739

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca