Version 5.4
Homo sapiens Gene: TSPAN32
Summary
InnateDB Gene IDBG-22280.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSPAN32
Gene Name tetraspanin 32
Synonyms ART1; PHEMX; PHMX; TSSC6
Species Homo sapiens
Ensembl Gene ENSG00000064201
Encoded Proteins
IDBP-22282
tetraspanin 32
IDBP-22288
tetraspanin 32
IDBP-22290
tetraspanin 32
IDBP-22294
tetraspanin 32
IDBP-361909
tetraspanin 32
IDBP-361945
tetraspanin 32
IDBP-361954
tetraspanin 32
IDBP-810475
tetraspanin 32
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene, which is a member of the tetraspanin superfamily, is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4, escapes imprinting. This gene may play a role in malignancies and diseases that involve this region, and it is also involved in hematopoietic cell function. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:2301997-2318200
Strand Forward strand
Band p15.5
Transcripts
ENST00000182290 ENSP00000182290
ENST00000381121 ENSP00000370513
ENST00000339046 ENSP00000343285
ENST00000381117 ENSP00000370509
ENST00000437313 ENSP00000405001
ENST00000446063 ENSP00000395018
ENST00000451520 ENSP00000405205
ENST00000461200
ENST00000493924
ENST00000484104
ENST00000479508
ENST00000498313
ENST00000483227
ENST00000493948
ENST00000484523
ENST00000486011
ENST00000612299 ENSP00000482901
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007010 cytoskeleton organization
GO:0007229 integrin-mediated signaling pathway
GO:0007267 cell-cell signaling
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0008285 negative regulation of cell proliferation
GO:0030886 negative regulation of myeloid dendritic cell activation
GO:0042832 defense response to protozoan
GO:0050688 regulation of defense response to virus
GO:0070527 platelet aggregation
Cellular Component
GO:0005622 intracellular
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0070442 integrin alphaIIb-beta3 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000244
View Gene Order
ENSBTAG00000002702
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_139022
HUGO
OMIM
CCDS CCDS7733
HPRD 04834
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca