InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: THRB

Summary

InnateDB Gene

IDBG-22332.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

THRB

Gene Name

thyroid hormone receptor, beta

Synonyms

C-ERBA-2; C-ERBA-BETA; ERBA2; GRTH; NR1A2; PRTH; THR1; THRB1; THRB2

Species

Homo sapiens

Ensembl Gene

ENSG00000151090

Encoded Proteins

IDBP-22334

thyroid hormone receptor, beta

IDBP-22336

thyroid hormone receptor, beta

IDBP-237009

thyroid hormone receptor, beta

IDBP-367979

thyroid hormone receptor, beta

IDBP-367986

thyroid hormone receptor, beta

IDBP-367992

thyroid hormone receptor, beta

IDBP-367997

thyroid hormone receptor, beta

IDBP-367998

thyroid hormone receptor, beta

IDBP-368001

thyroid hormone receptor, beta

IDBP-368006

thyroid hormone receptor, beta

IDBP-368009

thyroid hormone receptor, beta

IDBP-368010

thyroid hormone receptor, beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20018842

THRB signalling plays a role in modulating dendritic cell (DC) physiology and has immunoregulatory effects. THRB contains an NF-kappaB consensus site in its promoter region that controls its expression, which in turn signals DCs to promote maturation and function via an Akt-dependent, but PI3K independent pathway.

Entrez Gene

Summary

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:24117160-24495282

Strand

Reverse strand

Band

p24.2

Transcripts

ENST00000356447	ENSP00000348827
ENST00000280696	ENSP00000280696
ENST00000396671	ENSP00000379904
ENST00000453729	ENSP00000414910
ENST00000416420	ENSP00000414444
ENST00000413780	ENSP00000414100
ENST00000447875	ENSP00000388467
ENST00000415021	ENSP00000404898
ENST00000431815	ENSP00000395362
ENST00000447414	ENSP00000399573
ENST00000428492	ENSP00000404233
ENST00000418247	ENSP00000393932

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	72 [view]
Protein-Protein	71 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0003714	transcription corepressor activity
GO:0004887	thyroid hormone receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0031490	chromatin DNA binding
GO:0043565	sequence-specific DNA binding
GO:0070324	thyroid hormone binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007605	sensory perception of sound
GO:0007621	negative regulation of female receptivity
GO:0008016	regulation of heart contraction
GO:0008050	female courtship behavior
GO:0009887	organ morphogenesis
GO:0010467	gene expression
GO:0030522	intracellular receptor signaling pathway
GO:0043401	steroid hormone mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060509	Type I pneumocyte differentiation

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021779

View Gene Order

ENSBTAG00000017802

Not yet available

Pathways

NETPATH

NetPath_56

Prolactin pathway

REACTOME

REACT_15525

Nuclear Receptor transcription pathway pathway

REACT_12627

Generic Transcription Pathway pathway

REACT_71

Gene Expression pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

P10828

TrEMBL

UniProt Splice Variant

Entrez Gene

7068

UniGene

Hs.187861 Hs.605219 Hs.741539

RefSeq

NM_000461 NM_001128176 NM_001128177 NM_001252634 XM_005265420 XM_005265421 XM_005265423 XM_005265424 XM_005265425 XM_006713317 XM_006713318

HUGO

HGNC:11799

OMIM

190160

CCDS

CCDS2641

HPRD

07521

IMGT

EMBL

AC012087 AC093927 AC098971 AC099054 AC112217 AK096628 AY286465 AY286466 AY286467 AY286468 AY286469 AY286470 AY286471 BC106929 BC106930 CH471055 M26747 X04707 X74497

GenPept

AAA35677 AAI06930 AAI06931 AAQ23704 AAQ23705 AAQ23706 AAQ23707 AAQ23708 AAQ23709 AAQ23710 BAG53341 CAA28412 CAA52606 EAW64345

RNA Seq Atlas

7068