Version 5.4
Homo sapiens Gene: PRAME
Summary
InnateDB Gene IDBG-2240.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRAME
Gene Name preferentially expressed antigen in melanoma
Synonyms CT130; MAPE; OIP-4; OIP4
Species Homo sapiens
Ensembl Gene ENSG00000185686
Encoded Proteins
IDBP-232318
preferentially expressed antigen in melanoma
IDBP-232320
preferentially expressed antigen in melanoma
IDBP-292732
preferentially expressed antigen in melanoma
IDBP-292729
preferentially expressed antigen in melanoma
IDBP-292736
preferentially expressed antigen in melanoma
IDBP-292737
preferentially expressed antigen in melanoma
IDBP-365601
preferentially expressed antigen in melanoma
IDBP-365607
preferentially expressed antigen in melanoma
IDBP-365611
preferentially expressed antigen in melanoma
IDBP-365620
preferentially expressed antigen in melanoma
IDBP-587454
preferentially expressed antigen in melanoma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:22547701-22559361
Strand Reverse strand
Band q11.22
Transcripts
ENST00000398743 ENSP00000381728
ENST00000398741 ENSP00000381726
ENST00000405655 ENSP00000384343
ENST00000402697 ENSP00000385198
ENST00000406503 ENSP00000384058
ENST00000403441 ENSP00000385091
ENST00000439106 ENSP00000407320
ENST00000438888 ENSP00000407121
ENST00000420709 ENSP00000412318
ENST00000442481 ENSP00000399816
ENST00000492657
ENST00000476336
ENST00000485532
ENST00000543184 ENSP00000445675
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
Experimentally validated
Total 48 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042974 retinoic acid receptor binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006915 apoptotic process
GO:0008284 positive regulation of cell proliferation
GO:0030154 cell differentiation
GO:0040008 regulation of growth
GO:0043066 negative regulation of apoptotic process
GO:0045596 negative regulation of cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048387 negative regulation of retinoic acid receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt P78395
TrEMBL A0A024R1E6 B5MCY4 B5MD04 B7Z986 E7EMH2 E7EW99 F5H4B1 F8WF80
UniProt Splice Variant
Entrez Gene 23532
UniGene Hs.30743
RefSeq NM_001291715 NM_001291716 NM_006115 NM_206953 NM_206954 NM_206955 NM_206956
HUGO HGNC:9336
OMIM 606021
CCDS CCDS13801
HPRD
IMGT
EMBL AF025440 AK304593 AK312769 BC014074 BC022008 BC039731 CH471095 CR456549 D87011 D87013 U65011
GenPept AAC39560 AAC51160 AAH14074 AAH22008 AAH39731 BAG35634 BAH14222 CAG30435 EAW59518 EAW59519 EAW59520 EAW59521 EAW59522 EAW59523
RNA Seq Atlas 23532

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca