InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRAME

Summary

InnateDB Protein

IDBP-232320.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRAME

Protein Name

preferentially expressed antigen in melanoma

Synonyms

CT130; MAPE; OIP-4; OIP4;

Species

Homo sapiens

Ensembl Protein

ENSP00000381726

InnateDB Gene

IDBG-2240 (PRAME)

Protein Structure

UniProt Annotation

Function

Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. {ECO:0000269PubMed:16179254}.

Subcellular Localization

Nucleus {ECO:0000305PubMed:16620968}. Cell membrane {ECO:0000269PubMed:16620968}.

Disease Associations

Tissue Specificity

Expressed in testis. Detected in samples of kidney, brain and skin. {ECO:0000269PubMed:9047241}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.

Experimentally validated
Total	48 [view]
Protein-Protein	48 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042974	retinoic acid receptor binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0008284	positive regulation of cell proliferation
GO:0030154	cell differentiation
GO:0040008	regulation of growth
GO:0043066	negative regulation of apoptotic process
GO:0045596	negative regulation of cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048387	negative regulation of retinoic acid receptor signaling pathway