InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PLK2

Summary

InnateDB Gene

IDBG-22507.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLK2

Gene Name

polo-like kinase 2

Synonyms

hPlk2; hSNK; SNK

Species

Homo sapiens

Ensembl Gene

ENSG00000145632

Encoded Proteins

IDBP-22511

polo-like kinase 2

IDBP-811509

polo-like kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:58453982-58460260

Strand

Reverse strand

Band

q11.2

Transcripts

ENST00000274289	ENSP00000274289
ENST00000502671
ENST00000511326
ENST00000503378
ENST00000505244
ENST00000503713
ENST00000510629
ENST00000503115
ENST00000515415
ENST00000509555
ENST00000509422
ENST00000508300
ENST00000514306
ENST00000504196
ENST00000617412	ENSP00000478685

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0032403	protein complex binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0007052	mitotic spindle organization
GO:0007093	mitotic cell cycle checkpoint
GO:0007265	Ras protein signal transduction
GO:0007613	memory
GO:0032092	positive regulation of protein binding
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032486	Rap protein signal transduction
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046599	regulation of centriole replication
GO:0048167	regulation of synaptic plasticity
GO:0060291	long-term synaptic potentiation
GO:0060292	long term synaptic depression
GO:0061000	negative regulation of dendritic spine development

Cellular Component

GO:0005622	intracellular
GO:0005813	centrosome
GO:0005814	centriole
GO:0030425	dendrite

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021701

View Gene Order

ENSBTAG00000016771

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

plk_pathway

Polo-like kinase signaling events in the cell cycle

plk2_4pathway

PLK2 and PLK4 events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.398157

RefSeq

NM_001252226 NM_006622

HUGO

OMIM

CCDS

CCDS3974 CCDS75250

HPRD

06118

IMGT

EMBL

GenPept

RNA Seq Atlas