Version 5.4
Bos taurus Gene: PLK2
Summary
InnateDB Gene IDBG-628942.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLK2
Gene Name serine/threonine-protein kinase PLK2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000016771
Encoded Proteins
IDBP-680340
polo-like kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145632:
The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:20854607-20860584
Strand Forward strand
Band
Transcripts
ENSBTAT00000022307 ENSBTAP00000022307
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007052 mitotic spindle organization
GO:0007093 mitotic cell cycle checkpoint
GO:0007613 memory
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046599 regulation of centriole replication
GO:0048167 regulation of synaptic plasticity
Cellular Component
GO:0005813 centrosome
GO:0005814 centriole
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000145632
View Gene Order
ENSMUSG00000021701
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
plk_pathway
Polo-like kinase signaling events in the cell cycle
plk2_4pathway
PLK2 and PLK4 events
Cross-References
SwissProt
TrEMBL E1BP17
UniProt Splice Variant
Entrez Gene 539449
UniGene Bt.10259
RefSeq NM_001192245 XM_005221500
HUGO HGNC:19699
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02050295
GenPept
RNA Seq Atlas 539449

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca