Version 5.4
Homo sapiens Gene: CYP1A2
Summary
InnateDB Gene IDBG-22558.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP1A2
Gene Name cytochrome P450, family 1, subfamily A, polypeptide 2
Synonyms CP12; P3-450; P450(PA)
Species Homo sapiens
Ensembl Gene ENSG00000140505
Encoded Proteins
IDBP-22560
cytochrome P450, family 1, subfamily A, polypeptide 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme\'s endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3\' untranslated region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:74748844-74756202
Strand Forward strand
Band q24.1
Transcripts
ENST00000343932 ENSP00000342007
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0032451 demethylase activity
GO:0034875 caffeine oxidase activity
GO:0070330 aromatase activity
Biological Process
GO:0006706 steroid catabolic process
GO:0006725 cellular aromatic compound metabolic process
GO:0006778 porphyrin-containing compound metabolic process
GO:0006805 xenobiotic metabolic process
GO:0009403 toxin biosynthetic process
GO:0009404 toxin metabolic process
GO:0009791 post-embryonic development
GO:0009820 alkaloid metabolic process
GO:0010033 response to organic substance
GO:0010468 regulation of gene expression
GO:0014070 response to organic cyclic compound
GO:0016098 monoterpenoid metabolic process
GO:0017144 drug metabolic process
GO:0018894 dibenzo-p-dioxin metabolic process
GO:0019369 arachidonic acid metabolic process
GO:0019373 epoxygenase P450 pathway
GO:0030324 lung development
GO:0032259 methylation
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0032787 monocarboxylic acid metabolic process
GO:0035902 response to immobilization stress
GO:0042493 response to drug
GO:0042737 drug catabolic process
GO:0042738 exogenous drug catabolic process
GO:0044281 small molecule metabolic process
GO:0045333 cellular respiration
GO:0046483 heterocycle metabolic process
GO:0050665 hydrogen peroxide biosynthetic process
GO:0055114 oxidation-reduction process
GO:0070989 oxidative demethylation
GO:0071276 cellular response to cadmium ion
GO:0071615 oxidative deethylation
GO:0097267 omega-hydroxylase P450 pathway
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_150417
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) pathway
REACT_150134
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_13721
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 pathway
REACT_13543
Xenobiotics pathway
REACT_6946
Methylation pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_13567
Cytochrome P450 - arranged by substrate type pathway
REACT_228214
Aflatoxin activation and detoxification pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
hsa00380
Tryptophan metabolism pathway
hsa00830
Retinol metabolism pathway
hsa00591
Linoleic acid metabolism pathway
hsa00232
Caffeine metabolism pathway
hsa00140
Steroid hormone biosynthesis pathway
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
hsa00982
Drug metabolism pathway
INOH
INOH website
Tryptophan degradation pathway
PID NCI
Cross-References
SwissProt P05177
TrEMBL
UniProt Splice Variant
Entrez Gene 1544
UniGene
RefSeq NM_000761
HUGO HGNC:2596
OMIM 108330 124060
CCDS CCDS32293
HPRD 00489
IMGT
EMBL AF182274 AF253322 BC067424 BC067425 BC067426 BC067427 BC067428 DQ022432 L00384 L00385 L00386 L00387 L00388 L00389 M12078 M31664 M31665 M31666 M31667 M55053 Z00036
GenPept AAA35738 AAA52146 AAA52154 AAA52163 AAF13599 AAH67424 AAH67425 AAH67426 AAH67427 AAH67428 AAK25728 AAY26399 CAA77335
RNA Seq Atlas 1544

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca