InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP1A2

Summary

InnateDB Protein

IDBP-22560.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP1A2

Protein Name

cytochrome P450, family 1, subfamily A, polypeptide 2

Synonyms

CP12; P3-450; P450(PA);

Species

Homo sapiens

Ensembl Protein

ENSP00000342007

InnateDB Gene

IDBG-22558 (CYP1A2)

Protein Structure

UniProt Annotation

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O- deethylation of phenacetin. {ECO:0000269PubMed:14725854}.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019899	enzyme binding
GO:0020037	heme binding
GO:0032451	demethylase activity
GO:0034875	caffeine oxidase activity
GO:0070330	aromatase activity

Biological Process

GO:0006706	steroid catabolic process
GO:0006725	cellular aromatic compound metabolic process
GO:0006778	porphyrin-containing compound metabolic process
GO:0006805	xenobiotic metabolic process
GO:0009403	toxin biosynthetic process
GO:0009404	toxin metabolic process
GO:0009791	post-embryonic development
GO:0009820	alkaloid metabolic process
GO:0010033	response to organic substance
GO:0010468	regulation of gene expression
GO:0014070	response to organic cyclic compound
GO:0016098	monoterpenoid metabolic process
GO:0017144	drug metabolic process
GO:0018894	dibenzo-p-dioxin metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019373	epoxygenase P450 pathway
GO:0030324	lung development
GO:0032259	methylation
GO:0032355	response to estradiol
GO:0032496	response to lipopolysaccharide
GO:0032787	monocarboxylic acid metabolic process
GO:0035902	response to immobilization stress
GO:0042493	response to drug
GO:0042737	drug catabolic process
GO:0042738	exogenous drug catabolic process
GO:0044281	small molecule metabolic process
GO:0045333	cellular respiration
GO:0046483	heterocycle metabolic process
GO:0050665	hydrogen peroxide biosynthetic process
GO:0055114	oxidation-reduction process
GO:0070989	oxidative demethylation
GO:0071276	cellular response to cadmium ion
GO:0071615	oxidative deethylation
GO:0097267	omega-hydroxylase P450 pathway

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
IPR008066 Cytochrome P450, E-class, group I, CYP1

PFAM

PF00067

PRINTS

PR00385
PR00463
PR00465
PR01683

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P05177