Version 5.4
| Homo sapiens Gene: MPI | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-22813.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | MPI | ||||||||||||||||||
| Gene Name | mannose phosphate isomerase | ||||||||||||||||||
| Synonyms | CDG1B; PMI; PMI1 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000178802 | ||||||||||||||||||
| Encoded Proteins |
mannose phosphate isomerase
mannose phosphate isomerase
mannose phosphate isomerase
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. [provided by RefSeq, Jul 2008] Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 15:74890005-74902219 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q24.1 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Synthesis of GDP-mannose pathway
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
Asparagine N-linked glycosylation pathway
Post-translational protein modification pathway
Synthesis of substrates in N-glycan biosythesis pathway
Metabolism of proteins pathway
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| KEGG |
Amino sugar and nucleotide sugar metabolism pathway
Fructose and mannose metabolism pathway
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| INOH |
Aminosugars metabolism pathway
Fructose Mannose metabolism pathway
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| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | H3BPM5 H3BPU7 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 4351 | ||||||||||||||||||
| UniGene | Hs.75694 | ||||||||||||||||||
| RefSeq | NM_001289155 NM_001289156 NM_001289157 NM_002435 | ||||||||||||||||||
| HUGO | HGNC:7216 | ||||||||||||||||||
| OMIM | 154550 | ||||||||||||||||||
| CCDS | CCDS10272 CCDS73756 CCDS73757 CCDS73758 | ||||||||||||||||||
| HPRD | 01108 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC125435 | ||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 4351 | ||||||||||||||||||