Version 5.4
Mus musculus Gene: Mpi
Summary
InnateDB Gene IDBG-170302.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mpi
Gene Name mannose phosphate isomerase
Synonyms 1110002E17Rik; AI315153; Mpi-1; Mpi1
Species Mus musculus
Ensembl Gene ENSMUSG00000032306
Encoded Proteins
IDBP-170304
mannose phosphate isomerase
IDBP-541581
mannose phosphate isomerase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178802:
Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. [provided by RefSeq, Jul 2008]
Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:57544256-57552763
Strand Reverse strand
Band B
Transcripts
ENSMUST00000034856 ENSMUSP00000034856
ENSMUST00000140671
ENSMUST00000145543
ENSMUST00000156428 ENSMUSP00000119342
ENSMUST00000124593
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004476 mannose-6-phosphate isomerase activity
GO:0008270 zinc ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0009298 GDP-mannose biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000178802
View Gene Order
ENSBTAG00000005845
Not yet available
Pathways
NETPATH
REACTOME
REACT_248642
Synthesis of substrates in N-glycan biosythesis pathway
REACT_262413
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_198715
Synthesis of GDP-mannose pathway
REACT_237472
Asparagine N-linked glycosylation pathway
KEGG
mmu00520
Amino sugar and nucleotide sugar metabolism pathway
mmu00051
Fructose and mannose metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22423
Synthesis of GDP-mannose pathway
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
hsa00051
Fructose and mannose metabolism pathway
INOH
INOH website
Aminosugars metabolism pathway
INOH website
Fructose Mannose metabolism pathway
PID NCI
Cross-References
SwissProt Q924M7
TrEMBL Q3V100
UniProt Splice Variant
Entrez Gene 110119
UniGene
RefSeq NM_025837
OMIM
CCDS CCDS40650
HPRD
IMGT
MGI ID MGI:97075
MGI Symbol Mpi
EMBL AF244360 AK132777 BC051163 CH466522
GenPept AAH51163 AAK69388 BAE21353 EDL25909
RNA Seq Atlas 110119

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca