InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: COX5A

Summary

InnateDB Gene

IDBG-22937.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COX5A

Gene Name

cytochrome c oxidase subunit Va

Synonyms

COX; COX-VA; VA

Species

Homo sapiens

Ensembl Gene

ENSG00000178741

Encoded Proteins

IDBP-22939

cytochrome c oxidase subunit Va

IDBP-744921

IDBP-746855

IDBP-747298

IDBP-746971

IDBP-747133

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:74919791-74938168

Strand

Reverse strand

Band

q24.2

Transcripts

ENST00000322347	ENSP00000317780
ENST00000567270	ENSP00000457974
ENST00000568517	ENSP00000456314
ENST00000562233	ENSP00000456253
ENST00000564811	ENSP00000456386
ENST00000568783	ENSP00000455053

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004129	cytochrome-c oxidase activity
GO:0009055	electron carrier activity
GO:0046872	metal ion binding

Biological Process

GO:0022904	respiratory electron transport chain
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000000088

View Gene Order

ENSBTAG00000017267

Not yet available

Pathways

NETPATH

REACTOME

REACT_22393

Respiratory electron transport pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_6305

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway

REACT_267716

Orphan transporters pathway

REACT_111083

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_111217

Metabolism pathway

KEGG

hsa05010

Alzheimer's disease pathway

hsa00190

Oxidative phosphorylation pathway

hsa05012

Parkinson's disease pathway

hsa05016

Huntington's disease pathway

hsa04260

Cardiac muscle contraction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

H3BRI0

UniProt Splice Variant

Entrez Gene

9377

UniGene

Hs.574158 Hs.612964 Hs.732727

RefSeq

NM_004255

HUGO

HGNC:2267

OMIM

603773

CCDS

CCDS10273

HPRD

04799

IMGT

EMBL

AC125435

GenPept

RNA Seq Atlas

9377