Version 5.4
Homo sapiens Gene: ASGR2
Summary
InnateDB Gene IDBG-23219.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASGR2
Gene Name asialoglycoprotein receptor 2
Synonyms ASGP-R2; ASGPR2; CLEC4H2; HBXBP; HL-2
Species Homo sapiens
Ensembl Gene ENSG00000161944
Encoded Proteins
IDBP-23221
asialoglycoprotein receptor 2
IDBP-23227
asialoglycoprotein receptor 2
IDBP-364791
asialoglycoprotein receptor 2
IDBP-758280
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7101322-7115700
Strand Reverse strand
Band p13.1
Transcripts
ENST00000254850 ENSP00000254850
ENST00000355035 ENSP00000347140
ENST00000450034
ENST00000446679 ENSP00000405844
ENST00000574868 ENSP00000458835
ENST00000576487
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 16 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004873 asialoglycoprotein receptor activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0007166 cell surface receptor signaling pathway
GO:0009100 glycoprotein metabolic process
GO:0030282 bone mineralization
GO:0031647 regulation of protein stability
GO:0055088 lipid homeostasis
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040963
View Gene Order
ENSBTAG00000025101
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654440 Hs.731751
RefSeq NM_001181 NM_001201352 NM_080912 NM_080913 NM_080914 XM_005256645 XM_005256648 XM_006721522 XM_006721523 XM_006721525 XM_006721526
HUGO
OMIM
CCDS CCDS11088 CCDS32544 CCDS45598
HPRD 00152
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca