InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASGR2

Summary

InnateDB Protein

IDBP-23227.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASGR2

Protein Name

asialoglycoprotein receptor 2

Synonyms

ASGP-R2; ASGPR2; CLEC4H2; HBXBP; HL-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000347140

InnateDB Gene

IDBG-23219 (ASGR2)

Protein Structure

UniProt Annotation

Function

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Subcellular Localization

Membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Expressed exclusively in hepatic parenchymal cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	16 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004873	asialoglycoprotein receptor activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0007166	cell surface receptor signaling pathway
GO:0009100	glycoprotein metabolic process
GO:0030282	bone mineralization
GO:0031647	regulation of protein stability
GO:0055088	lipid homeostasis